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Bar charts showing an overall increase in expression of neuronal fibres expressing GLP-1R in the IBD group (n = 4) by image analysis of GLP-1R (E) and NF (F) in colonic biopsies (mean SEM, Mann Whitney U test)

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Alloxan hepatic metabolism may have been responsible for the increase in ALT/AST levels in diabetic animals, since the structural similarity with the glucose molecule allows its absorption by the cell through the GLUT2 transporter 38 , occasioning possible damage to cells which express this carrier

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An imbalanced gut microbiome can lead to poor absorption of these nutrients, which can directly affect thyroid hormone production and metabolism